Lipid Modification of Secreted Signaling Proteins
نویسندگان
چکیده
منابع مشابه
Lipid modification of secreted signaling proteins.
Proteins of the Hedgehog, Wnt and Epidermal Growth Factor Receptor (EGFR) ligand families are secreted signals that induce concentration-dependent responses in surrounding cells. Although these proteins must diffuse through the aqueous extracellular environment, recent work has shown that hydrophobic lipid modifications are essential for their functions. All three classes of ligands are palmito...
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The production of a functional protein does not end with the termination of the growing polypeptide chain. This, while clearly true of all proteins, is particularly obvious in the case of secretory proteins. While all proteins must fold to a functional conformation, and many must assemble into some supramolecular structure, secretory proteins must also make their way across membranes and throug...
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surprisingly large number of proteins in eukaryotic ceils are now known to contain covalently bound lipid. Several cell surface proteins, the Thy-1 glycoprotein (27, 55), acetylcholinesterase (14), alkaline phosphatase (28), and the variant surface glycoprotein of trypanosomes (13), among others, are anchored to the outer cell surface by a complex, glycosylated phospholipid (Table I; Fig. 1). A...
متن کاملMini-Review The Covalent Modification of Eukaryotic Proteins with Lipid
surprisingly large number of proteins in eukaryotic ceils are now known to contain covalently bound lipid. Several cell surface proteins, the Thy-1 glycoprotein (27, 55), acetylcholinesterase (14), alkaline phosphatase (28), and the variant surface glycoprotein of trypanosomes (13), among others, are anchored to the outer cell surface by a complex, glycosylated phospholipid (Table I; Fig. 1). A...
متن کاملLipid modification of proteins and its relevance to protein targeting.
Great advances in our knowledge of how proteins reach their final destinations in cells have been achieved in recent years; in particular the classical pathway of secretion via the endoplasmic reticulum and Golgi complex is now becoming understood in molecular detail (Rothman and Orci, 1990). However, a number of paradoxical examples of proteins which are apparently secreted, but not via this p...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2006
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.5.11.2804